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Out. 198. In vitro metabolism assays might initially concentrate on compound stability in the Optilns ence of hepatocytes, microsomes, or an S9 extract, but extend to drug interactions on a more restricted series because apparent metabolic stability may be a result of inhibition of P450 function.

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3 and Ohmic contacts at different gate voltages:V,-12 (dashedline)andV,-13. Although selection and transfection experiments have implicated these genes in the quinine response, their relative contribution to the trait and the way in which they interact with each other and additional genes to generate the specific drug response have not been elucidated.

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(After Hudson et al.Oncostatin M induces basic fibroblast growth factor expression in endothelial cells and promotes endothelial cell proliferation, migration and spindle morphology, J Cell Sci, 110 (Pt 7), 871, 1997.

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